Quick Answer: What Causes Slow Drug Metabolism?

At what age does metabolism slow down?

As we age, our metabolism slows and the rate at which we break down food decreases by 10 percent each decade after age 20.

Metabolism is the amount of energy (calories) your body uses to maintain itself..

Why do I metabolize drugs so slow?

Because of their genetic makeup, some people process (metabolize) drugs slowly. As a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective.

What factors affect metabolism of a drug?

Many factors affect the rate and pathway of metabolism of drugs, and the major influences can be sub-divided into internal (physiological and pathological) and external (exogenous) factors as indicated below: Internal: species, genetic (strain), sex, age, hormones, pregnancy, disease. External: diet, environment.

What are the phases of drug metabolism?

Drug metabolism reactions comprise of two phases: Phase I (functionalization) reactions such as oxidation, hydrolysis; and Phase II (conjugation) reactions such as glucuronidation, sulphate conjugation. Oxidation reactions are the most common and vital. These may occur at carbon, sulfur or nitrogen centre.

What medications slow down your metabolism?

Insulin is a growth hormone, which means it stimulates the body to create tissues, including fat cells. Slowed metabolism: Some drugs (like beta-blockers for high blood pressure) can cause the body’s metabolism to slow down, which means that calories are not burned as quickly.

What the body does to the drug?

Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption, bioavailability, distribution, metabolism, and excretion.

What are the factors affecting metabolism?

Your metabolic rate is influenced by many factors – including age, gender, muscle-to-fat ratio, amount of physical activity and hormone function.

What are the importance and consequences of drug metabolism?

The metabolism of a drug can have important consequences on its therapeutic effect or its toxicity. For this reason, early assessments of metabolic pathways in man help to foresee interindividual variation in drug response and elimination due to metabolism.

What is the main purpose of drug metabolism?

Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization; whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver.

What is first pass metabolism in the liver?

The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation.

Should genetics be considered before giving a person a drug?

There are several situations where genetic testing before starting a medication is standard of care today. When there is a well-understood drug-gene interaction, knowing the genotype before starting treatment can avoid dangerous side effects.

How liver disease affect drug metabolism?

Cirrhosis causes changes in the architecture of the liver leading to changes in blood flow, protein binding, and drug metabolizing enzymes. Drug metabolizing enzymes are primarily decreased due to loss of liver tissue. However, not all enzyme activities are reduced and some are only altered in specific cases.

What does decreased metabolism of a drug mean?

If the substances increase the ability of the enzymes to break down a drug, then that drug’s effects are decreased. Because metabolic enzyme systems are only partially developed at birth, newborns have difficulty metabolizing certain drugs.

Does peanut butter slow down metabolism?

Your metabolism will slow down if you lose too much muscle, making continued weight loss more difficult. Including protein-rich foods, such as peanut butter, in a reduced-calorie diet may boost fat loss more than the same diet without sufficient protein ( 7 , 8 ).

How do you fix a slow metabolism?

10 Easy Ways to Boost Your Metabolism (Backed by Science)Eat Plenty of Protein at Every Meal. Eating food can increase your metabolism for a few hours. … Drink More Cold Water. … Do a High-Intensity Workout. … Lift Heavy Things. … Stand up More. … Drink Green Tea or Oolong Tea. … Eat Spicy Foods. … Get a Good Night’s Sleep.More items…