What Are The Side Effect Of Chloramphenicol?

What is the strongest antibiotic for bacterial infection?

Drugs used to treat Bacterial InfectionDrug nameRatingRx/OTCFlagyl6.3RxGeneric name: metronidazole systemic Drug class: amebicides, miscellaneous antibiotics For consumers: dosage, interactions, side effects For professionals: Prescribing InformationAzithromycin Dose Pack7.0Rx73 more rows.

Can humans take chloramphenicol?

Chloramphenicol is used in a wide variety of infections in dogs, cats, and horses. Unfortunately, a major drawback to chloramphenicol is a rare but very serious health risk for humans who handle this drug. See precautions. Chloramphenicol is FDA approved for use in dogs, but it is not approved in cats or horses.

What are the side effects of chloramphenicol eye drops?

Common side effects Chloramphenicol eye drops or ointment can cause stinging or burning in your eye. This happens straight after using the eye drops or ointment and only lasts for a short time. Do not drive or operate machinery until your eyes feel comfortable again and your vision is clear.

What type of bacteria does chloramphenicol kill?

It has a role as an antimicrobial agent, an antibacterial drug, a protein synthesis inhibitor, an Escherichia coli metabolite and a Mycoplasma genitalium metabolite.

What infections does chloramphenicol treat?

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.

How long does chloramphenicol last once opened?

Once opened, chloramphenicol eye drops/ointment should not be kept for longer than 4 weeks.

What does chloramphenicol do to bacteria?

Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Why is chloramphenicol banned?

The Committee concluded that the compound is genotoxic, which means it could cause genetic damages and possibly lead to cancer. Chloramphenicol is also known to cause an extremely serious disease in people called “aplastic anemia”.

How do I know if I have bacterial or viral conjunctivitis?

Viral conjunctivitis usually lasts longer than bacterial conjunctivitis. If conjunctivitis does not resolve with antibiotics after 3 to 4 days, the physician should suspect that the infection is viral. Bacterial conjunctivitis is characterized by mucopurulent discharge with matting of the eyelids.

Why is chloramphenicol toxic to humans?

Its mechanism of action is by inhibition of bacterial protein synthesis by binding with ribosomes. The major toxicity of chloramphenicol is hematological. In all vertebrates studied, it produces direct, dose-dependent bone marrow depression resulting in reductions in red blood cells, white blood cells, and platelets.

Is chloramphenicol a broad spectrum antibiotic?

Chloramphenicol is a broad-spectrum antibiotic that interferes with mitochondrial protein synthesis and is active against a variety of organisms including salmonelloses not responsive to ampicillin.

Can you use too much chloramphenicol?

If you use more chloramphenicol than you should If you accidently apply too much drops, you should wash your eye with plenty of water, if any painful symptoms continue after this, you should tell your doctor immediately.

What is the best antibiotic for eye infection?

Patients with symptoms should be referred immediately to an ophthalmologist. Oral antibiotics such as azithromycin or doxycycline are effective treatments.

Is chloramphenicol contraindicated in?

Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it. It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat.

Can chloramphenicol make eye worse?

Chloramphenicol drops and ointment can occasionally cause mild eye irritation or stinging, but these usually soon pass and not everyone will experience them. If the irritation continues, or if you experience any other eye problems, please speak with your doctor or pharmacist for advice.

Is chloramphenicol a steroid?

GENERIC NAME: CHLORAMPHENICOL/HYDROCORTISONE – EYE-EAR OINTMENT (klor-am-FEN-eh-coal/hi-dro-KOR-tih-sown) USES: This medication contains an antibiotic that helps prevent or treat an infection and a steroid which reduces inflammation. It is used in the treatment of various eye (ophthalmic) or ear (otic) conditions.

What happens if chloramphenicol is not refrigerated?

Thermal degradation of chloramphenicol occurs at a faster rate when stored in unrefrigerated conditions. This study measures the concentration of the principal thermal breakdown product of generic chloramphenicol eye-drops being sold over the counter in chemists in different locations in India.

How long do eye antibiotics take to work?

Antibiotics should start clearing up the infection within 24 hours of starting to use them. Even if you don’t use antibiotics, mild bacterial pink eye almost always improves within 10 days.